HomeContact: s.basu@qmul.ac.uk
Professional interests
Subham Basu is a CR-UK Principle Investigator. He recieved his undergraduate degree in neuroscience at the University of California, Berkeley. He went on to complete a PhD in Molecular Pharmacology at the Cornell University Graduate School of Medical Sciences, working at the Sloan Kettering Institute in New York on Ras-Raf signalling and apoptosis. Moving to London in 1999, he extended these studies to examine Akt signalling and apoptosis in a postdoctoral fellowship in Julian Downward's laboratory at the ICRF. Since 2003, he has led his own group, first at Hammersmith Hospital and now at Charterhouse Square, in investigating how different proteins which are involved in regulating DNA-damage and survival signalling are deregulated in tumourigenesis. In particular, current studies focus on the Akt pathway in both the regulation of apoptosis and metabolism and the p53 pathway in stress and chemosensitivity. Though emphasis has been on cell culture models of epithelial maligancies such as breast cancer, the lab is expanding into examining haemopoietic cancers and also animal models.
Research Team:
| Ms Phuong Luong | Research associate |
| Mr Daniel Sears | PhD student co-supervised with Prof. J.V. Melo, Imperial College |
| Dr Victoria Tomlinson | Postdoctoral research fellow |
Dr Tobias Maile |
Postdoctoral research fellow in conjunction with Dr Nic Tapon, London Research Institute |
| TBA | Postdoctoral research fellow |
Funding:
CRUK Programme Grant 2003-2009 £880,000
Recent Publications:
- Downward J and Basu S. YAP and p73: a complex affair. Molecular Cell 2008;32(6):749-50.
- Mastino A, Basu S, Brunner T, Ricci JE, Diederich M. Long live the cell death! Cell Death and Differentiation 2008;15(8):1330-2 .
- Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C, Smith P, Danovi SA, Pardo O, Crook T, Mein CA, Lemoine NR, Jones LJ, Basu S. Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death and Differentiation 2008;15(11):1752-9.
- Danovi SA, Rossi M, Gudmundsdottir K, Yuan M, Melino G, Basu S. Yes-associated protein (YAP) is a critical mediator of c-Jun-dependent apoptosis. Cell Death and Differentiation 2008;15(1):217-9.
- Wan H, Yuan M, Simpson C, Allen K, Gavins FNE, Ikram MS, Basu S, Baksh N, O’Toole EA, Hart IR . Stem/progenitor cell-like properties of Desmoglein 3dim cells in primary and immortalized keratinocyte lines. Stem Cells 2007;25:1286-97.
- Yoshida C, Yoshida F, Sears DE, Hart SM, Ikebe D, Muto A, Basu S, Igarashi K, Melo JV. Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. Blood 2007;109:1211-9.
- Musat M, Korbonits M, Kola B, Borboli N, Hanson MR, Nanzer AM, Grigson J, Jordan S, Morris DG, Gueorguiev M, Coculescu M, Basu S, Grossman AB. Enhanced protein kinase B/Akt signalling in pituitary tumours. Endocr Relat Cancer 2005;12:423-33.
- Basu S. Akt Inhibits DNA damage by suppressing Forkhead, p53, p73 or all three? Cell Cycle 2003;2:69-70.
- Basu S, Totty NF, Irwin, MS, Sudol M, Downward J. Akt phosphorylates the Yes-associated protein YAP to induce interaction with 14-3-3 and attenuation of p73-induced apoptosis. Molecular Cell 2003;11:11-13.
