Contact: D.Berney@bartsandthelondon.nhs.uk

Professional interests

Dan Berney trained at Cambidge and UCL and then became a registrar at Barts and The London. He was appointed consultant Histopathologist in 1998 and developed an interest in genito-urinary malignancies both clinically and in research. This was developed by the formation of The Orchid Tissue Laboratory, funded by The Orchid Appeal conducting translational research into male cancers. He was appointed honorary reader in 2007. The focus of his research is prostate, penile and testicular cancers, using tissue micro-array to create high throughput arrays to examine numerous biomarkers.

In prostate cancer the focus is biomarker discovery. In particular, this is the biological examination of a unique cohort of over 2000 prostate cancers treated conservatively in the 1990s, together with the Trans-Atlantic Prostate Group in collaboration with Prof J Cuzick at the Dept of Mathematics, Statistics and Epidemiology. This cohort has already been the focus of numerous papers, and in 2008 Dr Berney was awarded a CRUK Translational grant for further research into the biopsy specimens of this cohort.
In testis cancer, Dr Berney in the custodian of the British testicular Tumour Panel collection, which is the focus of ongoing studies, as well as providing pathological support for clinical trials, and work on the pathogenetic pathways of testicular cancer.

In penile cancer, with the support of a grant from The Jean Shanks Foundation, Dr Berney has created a tissue microarray of this rare cancer to study penile cancer pathogenesis in relation to HPV infection. This work is in collaboration with Dr C Corbishley and Dr N Watkin at St George’s Hospital.

Research Team:

Dr Isabelle Bisson	Tissue Bank Manager
Ms S Kudahetti	Research Technician
Ms E Stankiewicz	Research Technician

 

Funding:

The Orchid Appeal Yearly Grant 2008-9 £130,000

CR-UK Translational Grant, 3 years £180,000 "To tissue microarray and perform biomarker analysis on the biopsy specimens from the Trans-Atlantic Prostate Group Cohort".

The Jean Shanks Foundation 2/3year grant £90000 "Tissue micro-array analysis of penile cancers"

Recent Publications:

• Mao X, Shaw G, James SY, Purkis P, Kudahetti SC, Tsigani T, Kia S, Young BD, Oliver RTD, Berney D, Prowse DM, Lu Y-J. Detection of TMPRSS2:ERG fusion gene in circulating prostate cancer cells Asian Journal of Andrology 2008;in press.
• Rajab R, Berney DM. Ten Testicular Trapdoors. Histopathology 2008;53(6):728-39.
• Berney DM, Adlan AMA, Kandahetti S, Biedrzycki O, Hadway P, Watkin N, Corbishley C, Oliver RTD. DNA Topoisomerase I and IIa expression in penile carcinomas: assessing potential tumor chemosensitivity. BJU Int 2008;102(8):1040-4.
• Eastham JA, Kattan MW, Fearn P, Fisher G, Berney DM, Oliver T, Foster CS, Møller H, Reuter V, Scardino P, Cuzick J, and the Transatlantic Prostate Group. Local Progression Among Men With Conservatively Treated Localized Prostate Cancer: Results from the Transatlantic Prostate Group. Eur Urol 2008;53(2):347-54.
• Berney DM, Warren A, Verma M, Kudahetti S, Williams M, Neal D, Powles T, Shamash J, Oliver RTD. Malignant Germ Cell Tumors in the Elderly. A Histopathological Review of 50 cases in men aged 60 or over. Mod Pathol 2008;21(1):54-9.
• Berney DM. Staging and classification of testicular tumours: pitfalls from macroscopy to diagnosis. J Clin Path 2008;61(1):20-4.
• Attard G, Clark J, Ambroisine L, Fisher G, Kovacs G, Flohr P, Berney D, Foster C, Fletcher A, Gerald WL, De Bono JS, Scardino P, J Cuzick J, Cooper CS on behalf of the Transatlantic Prostate Group.Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer Oncogene 2008;27(3):253-63.
• Kattan MW, Cuzick J, Fisher G, Berney DM, Oliver T, Foster CS, Møller H, Reuter V, Fearn P, Eastham J, Scardino PT and the Transatlantic Prostate Group. Nomogram incorporating PSA level to predict cancer-specific survival for men with clinically localized prostate cancer managed without curative intent. Cancer 2008;112(1):69-74.
• Shamash J, Powles T, Ansell W, Berney D, Mutsvangwa K, Wilson P, Asterling S, Liu S, Wyatt P, Joel SP, and Oliver RTD. GAMEC- an intensive protocol for untreated IGCCCG poor prognosis germ cell tumors and relapsed or refractory cases failing at least one line of platinum based therapy. BJC 2007;97(8):1188.
• Berney DM, Fisher G, Kattan M, Oliver RTD, Møller H, Fearn P, Eastham J, Scardino P, Cuzick J, Reuter VE, Foster CS. Major shifts in the treatment and prognosis of prostate cancer due to changes in pathological diagnosis and grading. BJU Int 2007;100(6):1240-4.
• Berney DM Low grade Gleason score Adenocarcinomas are no longer viable entities. Histopathology 2007;50(6):683-90.
• Verma M, Al Hakim A, Berney DM. Carcinosarcoma arising in a yolk sac tumour. Pathology 2007;39(6):601-3.
• Shamash J, Powles T, Mutsvangwa K, Wilson P, Ansell W, Walsh E, Berney D, Stebbing J, Oliver RTD. A phase II study using a topoisomerase I-based approach in patients with multiply relapsed germ-cell tumours. Ann Onc 2007;18(5):925-30.
• Berney DM. The case for modification of the Gleason grading system BJU Int 2007;100(4):725-6.
• Berney DM, Fisher G, Kattan M, Oliver RTD, Møller H, Fearn P, Eastham J, Scardino P, Cuzick J, Reuter VE, Foster CS. Pitfalls in the diagnosis of prostate cancer: retrospective review of 1791 cases with clinical outcome Histopathology 2007;51(4):452-7.
• Winstanley AM, Landon G, Berney DM, Minhas S, Fisher C, Parkinson MC. The Immunocytochemical profile of mesotheliomas of the tunica vaginalis-a study of 20 cases. Am J Surg Path 2006;30(1):1-6.
• Berney DM, Lee A, Shamash J, Oliver RTD. The association between intratubular seminoma and invasive germ cell tumours Hum Path 2006;37(4):458-61.
• Carvajal-Carmona LG, Alam NA, Pollard P, Jones AM, Barclay E, Wortham N, Pignatelli M, Freeman A, Pomplun S, Ellis I, Poulsom R, El-Bahrawy MA, Berney DM, Tomlinson IPM. Adult Leydig-cell tumours caused by germline mutations in the fumarate hydratase gene J Clin Endo and Met 2006 ;91(8):3071-5.
• Cuzick J, Fisher G, Kattan MW, Berney D, Oliver T, Foster CS, Møller H, Reuter V, Fearn P, Eastham J, Scardino P on behalf of the Transatlantic Prostate Group. Long-Term Outcome Among Men With Conservatively Treated Localized Prostate Cancer. British Journal of Cancer 2006;95(9):1186-94.
• Ogilvie CM, Brown PL, Matson M, Dacie J, Reznek RH, Britton K, Carpenter R, Berney D, Drake WM, Jenkins PJ, Chew SL, Monson JP. Selective parathyroid venous sampling in patients with complicated hyperparathyroidism. Eur J Endocrinol 2006;155(6):813-21.
• Berney DM. A practical approach to the diagnosis of testicular germ cell tumours Current Diagnostic Pathology Drake WM, Berney DM, Kovacs K, Monson JP. Markers of cell proliferation in a GH-producing adenoma of a patient treated with pegvisomant. Eur J Endocrinol 2005;153(2):203-5.
• Varma M, Berney DM, Jasani B, Rhodes A. Inter-laboratory Survey of Technical Variations in Prostatic Immunohistochemistry: Basal cell markers. Immunocytochemistry. 2005;3:124-7.
• Bhardwa JM, Powles T, Berney D, Baithun S, Nargund VH, Oliver RT. Assessing the size and stage of testicular germ cell tumours: 1984-2003. BJU Int 2005;96(6):819-21.
• Berney DM, Lee A, Shamash J, Oliver RTD. The frequency and distribution of intratubular trophoblast in association with germ cell tumors of the testis. Am J Surg Path 2005;29(10):1300-3.
• Lu YJ, Yang J, Noel E, Skoulakis S, Chaplin T, Raghavan M, Purkis T, McIntyre A, Kudahetti SC, Naase M, Berney D, Shipley J, Oliver RT, Young BD. Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development. Cancer Res 2005;65(20):9137-41.
• Berney DM. Comment on public survey on human tissue use J Clin Path 2004;57: 782-3.
• Hitchings AN, Kumar M, Jordan S, Nargund V, Martin J, Berney DM. Prediction of progression with p53, rb and p16 in pTa and pT1 transitional cell carcinoma. British Journal Cancer 2004;91:552-7.
• Varma M, Berney DM, Jasani B, Rhodes A. Technical Variations In Prostatic Immunohistochemistry: Need For Standardisation And Stringent Quality Assurance In PSA And PSAP Immunostaining J Clin Pathol 2004;57:687-90.
• Berney DM, Randle S, Shamash J, Lee A, Oliver RTD. The Distribution, Immunochemistry and variants of intratubular embryonal carcinoma of the testis. Histopathology 2004;45:155-161.
• Giri SK, Berney DM, O'Driscoll J, Drumm J, Flood HD, Gupta RK. Choriocarcinoma arising from an intra-abdominal testis in a patient with persistent Müllerian duct syndrome. Lancet Oncology 2004;5:451-2.
  

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