Contact: c.chelala@qmul.ac.uk

Professional interests

Dr Claude Chelala joined the Institute of Cancer in 2006.

She was awarded a PhD in Radiation Biology from the University of Paris XI in 2002 and a degree in Structural Bioinformatics from the University of Paris Descartes. Her first post-doctoral experience at the National Center for Scientific Research (CNRS) involved the development of novel tools to gather information for automated analysis of genome maps and distribution study of the disease-related genes. Afterwards, she joined the Pasteur Institute to work on large-scale analysis of genetic variation, integration with clinical data and the association with type 1 diabetes. She worked on developing tools to transfer, integrate and analyse the genetic, genomic and proteomic data.

Her research interests lie in the area of computational and integrative bioinformatics. She is currently leading and developing the following projects:

• Design and implementation of a generic model for the organization, integration and mining of complex data for cancer research. The model was successfully applied to pancreatic cancer and could be extended to any malignant or non-malignant disease where complex data are available.
  
• Capturing Single Nucleotide Polymorphisms (SNPs) from next-generation sequencing data: Mapping, Integration and Functional annotation. The first pilot model is available at www.snp-nexus.org
  
• Large-scale meta-analysis of common/specific alteration signatures in human cancers

Research Team:

Ms Emanuela Gadaleta	Research Assistant
Dr Tiffany Morris	Postdoctoral Research Fellow
Dr Ros Cutts	Bioinformatician

 

Recent Publications:

• Chelala C, Khan A, Lemoine NR. SNPnexus: A web database for functional annotation of newly discovered and public domain Single Nucleotide Polymorphisms, Bioinformatics 2009;25(5):655-61.
• Chelala C, Lemoine NR, Hahn S, Crnogorac-Jurcevic T. A web-based platform for mining pancreatic expression datasets. Pancreatology 2009;9(4):340-3.
• Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR. Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology 2009;9(1-2):13-24.
• Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C, Smith P, Danovi SA, Pardo O, Crook T, Mein CA, Lemoine NR, Jones LJ, Basu S. Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ 2008;15(11):1752-9.
• Raghavan M, Smith L, Lillington DM, Chaplin T, Kakkas I, Molloy G, Chelala C, Fitzgibbon J, Lister AT, Young BD. Segmental uniparental disomy is the most commonly acquired genetic event in relapsed acute myeloid leukemia. Blood 2008;112(3):814-21.
• Gupta M, Raghavan M, Gale R, Chelala C, Linch D, Cazier JB, and Young BD. A genome-wide map of acquired uniparental disomy in acute myeloid leukaemia. Genes, Chromsomes and Cancer 2008;47(9):729-39.
• Harada T, Chelala C, Bhakta V, Chaplin V, Caulee K, Baril P, Young BD, Lemoine NR. Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene 2008;27(13):1951-60.
• Chelala C, Hahn SA, Whiteman HJ, Barry S, Hariharan D, Radon TP, Lemoine NR, Crnogorac-Jurcevic T. Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets. BMC Genomics 2007;8:439.
• Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, Lemoine N. S100A4 contributes to the suppression of BNIP3 expression, chemoresistance and inhibition of apoptosis in pancreatic cancer. Cancer Research 2007;67(14):6786-95.
• Chelala C, Duchatelet S, Joffret ML, Bergholdt R, Dubois-Laforgue D, Ghandil P, Pociot F, Caillat-Zucman S, Timsit J, Julier C. PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits. Diabetes 2007;56:522-6.
• Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC, Lemoine NR. Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation. British Journal of Cancer 2007;96:373-82.
• *Senee V, *Chelala C, *Duchatelet S, Feng D, Blanc, H, Cossec JC, Charron C, Nicolino M, Boileau P, Cavener DR, Bougneres P, Taha D, Julier C. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nature Genetics 2006;38:682-7.
  *Authors contributed equally to this work
• Ghandil P, Chelala C, Dubois-LaforgueD, Senee V, Caillat-ZucmanS, Kockum I, Luthman H, Nerup J, Pociot F, Timsit J, Julier C. Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes. Molecular Genetics and Metabolism 2005;86:379-83.
• Chelala C, Auffray C. Sex-linked recombination variation and distribution of disease-related genes on chromosomes 21 and 22. Gene 2005;346:29-39.
• Imanishi T, Itoh T, Suzuki Y, O'Donovan C, Fukuchi S, Koyanagi KO, Barrero RA, Tamura T, Yamaguchi-Kabata Y, Tanino M, Yura K, Miyazaki S, Ikeo K, Homma K, Kasprzyk A, Nishikawa T, Hirakawa M, Thierry-Mieg J, Thierry-Mieg D, Ashurst J, Jia L, Nakao M, Thomas MA, Mulder N, Karavidopoulou Y, Jin L, Kim S, Yasuda T, Lenhard B, Eveno E, Suzuki Y, Yamasaki C, Takeda J, Gough C, Hilton P, Fujii Y, Sakai H, Tanaka S, Amid C, Bellgard M, Bonaldo Mde F, Bono H, Bromberg SK, Brookes AJ, Bruford E, Carninci P, Chelala C, Couillault C, de Souza SJ, Debily MA, Devignes MD, Dubchak I, Endo T, Estreicher A, Eyras E, Fukami-Kobayashi K, Gopinath GR, Graudens E, Hahn Y, Han M, Han ZG, Hanada K, Hanaoka H, Harada E, Hashimoto K, Hinz U, Hirai M, Hishiki T, Hopkinson I, Imbeaud S, Inoko H, Kanapin A, Kaneko Y, Kasukawa T, Kelso J, Kersey P, Kikuno R, Kimura K, Korn B, Kuryshev V, Makalowska I, Makino T, Mano S, Mariage-Samson R, Mashima J, Matsuda H, Mewes HW, Minoshima S, Nagai K, Nagasaki H, Nagata N, Nigam R, Ogasawara O, Ohara O, Ohtsubo M, Okada N, Okido T, Oota S, Ota M, Ota T, Otsuki T, Piatier-Tonneau D, Poustka A, Ren SX, Saitou N, Sakai K, Sakamoto S, Sakate R, Schupp I, Servant F, Sherry S, Shiba R, Shimizu N, Shimoyama M, Simpson AJ, Soares B, Steward C, Suwa M, Suzuki M, Takahashi A, Tamiya G, Tanaka H, Taylor T, Terwilliger JD, Unneberg P, Veeramachaneni V, Watanabe S, Wilming L, Yasuda N, Yoo HS, Stodolsky M, Makalowski W, Go M, Nakai K, Takagi T, Kanehisa M, Sakaki Y, Quackenbush J, Okazaki Y, Hayashizaki Y, Hide W, Chakraborty R, Nishikawa K, Sugawara H, Tateno Y, Chen Z, Oishi M, Tonellato P, Apweiler R, Okubo K, Wagner L, Wiemann S, Strausberg RL, Isogai T, Auffray C, Nomura N, Gojobori T, Sugano S. Integrative Annotation of 21, 037 Human Genes Validated by Full-Length cDNA Clones. PLoS Biol 2004;2:e162.
• Eveno E, Mariage-Samson R, Bortoli S, Imbeaud S, Decraene C, Piétu G, Chelala C, Devignes MD, Auffray C. The Genexpress IMAGE Knowledge Base of the Human Genome and Transcriptomes. In: Lorkowski S, Cullen PM editors. Analysing Gene Expression, A Handbook of Methods: Possibilities and Pitfalls. Weinheim: Wiley-VCH, 2002 p769-871.
• Chelala C, Devignes MD, Imbeaud S, Curis E, Bénazeth S, Zoorob R, Cox DR, Auffray C. Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related loci. Journal of Biological Systems 2002;10:303-17.
• Chelala C, Imbeaud S, Devignes MD, Zoorob R, Auffray C. Refined localisation of twenty-one genes in subregion p13.1 of human chromosome 1. Cytogenetics and Cell Genetics 2001;92:209-12.
  

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