Contact: p.cutillas@qmul.ac.uk

Professional interests

I joined the Institute of Cancer on January 2007. My previous position was at the Ludwig Institute for Cancer Research where I performed postdoctoral research in the laboratory of Bart Vanhaesebroeck. My work there involved designing and applying advanced techniques for protein analysis, and focused on the study of cell signalling pathways controlled by a group of enzymes termed PI3 kinases.

My current research focuses on understanding the basic principles by which cell signalling pathways operate and how these are subverted in disease. Our research involves the use of mass spectrometry and related analytical techniques to quantify the activity of cell signalling pathways and to understand their contribution to the signalling network. Our goal is to decipher how these networks are deregulated in cancer cells and to translate these findings to the design of rational therapies.

Recent Publications:

• Cutillas PR, Vanhaesebroeck B. Quantitative profile of a mouse core proteome using novel informatics tools for label-free functional proteomics. Mol Cell Proteomics 2007;6(9):1560-73.
• Norden AG, Cutillas PR, Unwin RJ. Clinical urinary peptidomics: learning to walk before we can run. Clin Chem 2007;53:375-6.
• Geering B, Cutillas PR, Vanhaesebroeck B. Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits? Biochem Soc Trans 2007; 35:199-203.
• Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B. Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers. Proc Natl Acad Sci U S A 2007; 104:7809-14.
• Vilasi A, Cutillas PR, Maher AD, Zirah SF, Capasso G, Norden AW, Unwin R. Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome. Am J Physiol Renal Physiol 2007;;293(2):F456-67.
• Cutillas PR, Khwaja A, Graupera M, Pearce W, Gharbi S, Waterfield M, Vanhaesebroeck B Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry. Proc Natl Acad Sci U S A 2006; 103:8959-64.
• Cutillas PR, Geering B, Waterfield MD, Vanhaesebroeck B. Quantification of Gel-separated Proteins and Their Phosphorylation Sites by LC-MS Using Unlabeled Internal Standards: Analysis of Phosphoprotein Dynamics in a B Cell Lymphoma Cell Line. Mol Cell Proteomics 2005;4:1038-51.
• Cutillas PR, Biber J, Marks J, Jacob R, Stieger B, Cramer R, Burlingame AL, Unwin RJ. Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex. Proteomics 2005; 5:101-12.
• Cutillas PR. Principles of Nanoflow Liquid Chromatography and Applications to Proteomics. Current Nanoscience 2005; 1:65-71.
  

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