Contact: hemant.kocher@bartsandthelondon.nhs.uk

Professional Interests

Mr Hemant Kocher joined the Institute of Cancer in February 2005, as a Senior Clinical Lecturer, having been awarded a National Clinician Scientist Fellowship by the National Institute of Health Research (UK). He completed his MD at King's College London under the supervision of Prof. Bruce M Hendry and Prof. Irving S Benjamin in 2003 and completed his specialist clinical training in hepato-biliary-pancreatic surgery under Prof. Irving S Benjamin and Prof. Nigel Heaton in 2005. His current research interests include pancreatic cancer progression with special reference to the stromal reaction in pancreatic cancer. Current research directions include

• Investigating the role of Ezrin, RhoC and ROCK in pancreatic cancer progression, invasion and metastasis
• Investigating the role of pancreatic stellate cells.
• Developing organotypic pancreatic cancer models.

His clinical interests include clinical trials and epidemiology in patients with hepato-biliary-pancreatic disorders, surgical development and his clinical practice is at the Barts and the London HPB Centre at the Royal London Hospital.

Personal awards/fellowship include the Young Fellow Award of the Royal Society of Medicine (2005) and Cutler's Surgical Fellowship (2007).

Research Team:

Funding:

Lewin International Surgical Oncology Fund 2009-11 £20,000 "Modulating stroma of pancreatic cancer"

Pancreatic Cancer Research Fund: Howard Kerr PhD Studentship 2009-12 £122,000 "Development of imaging and therapy of pancreatic cancer by targeting the integrin αvβ6" (joint with Dr John Marshall)

Research Advisory Board, Queen Marys University of London/ MRC. Pump priming grant 2007-2008 £7,500 "Investigating role of pancreatic stellate cell quiescence"

NHS Research Capacity Development. DoH National Clinician Scientist Award 2005-2010 £864,000 "The role of tumour cell and stromal cell interactions in modulating the invasive behaviour of pancreatic cancer"

Research Advisory Board, Queen Marys University of London/ MRC. PhD Studentship 2007-2010 £78,000 "Development of organotypic culture models for pancreatic cancer"

Recent Publications:

• Ahmed I, Fotiadis NI, Dilks P, Kocher HM, Fotheringham T, Matson M. Multiple Intrahepatic Artery Aneurysms in a Patient with Behçet's Disease: Use of Transcatheter Embolization for Rupture. Cardiovasc Intervent Radiol 2009;in press.
• Smith M, Kocher HM, Hunt BJ. Aprotinin in severe acute pancreatitis. Int J Clin Pract 2009;in press.
• Jawad N, Wolff A, Chin-Aloeng J, Greaves R, Kocher HM. Biliary Cystadenoma causing obstructive jaundice. Case Rep Gastroenterol 2009;in press.
• Froeling FE, Mirza TA, Feakins RM, Seedhar A, Elia G, Hart IR, Kocher HM. Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells. Am J Pathol 2009;175(2):636-48.
• Fellous TG, McDonald SA, Burkert J, Humphries A, Islam S, De-Alwis NM,Gutierrez-Gonzalez L, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, El-Bahrawy M, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Day CP, Wright NA, Alison MR. A methodological approach to tracing cell lineage in human epithelial tissues. Stem Cells 2009;27(6):1410-20.
• Kocher HM, Sandle J, Mirza TA, Li NF, Hart IR. Ezrin interacts with cortactin to form podosomal rosettes in pancreatic cancer cells. Gut 2009;58(2):271-84.
• Li NF, Kocher HM, Salako MA, Obermueller E, Sandle J, Balkwill F. A novel function of colony-stimulating factor 1 receptor in hTERT immortalization of human epithelial cells. Oncogene 2009;28(5):773-80.
• Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Taylor G, McDonald SA, Wright NA, Alison MR. Locating the stem cell niche and tracing hepatocyte lineages in human liver. Hepatology 2009;49(5):1655-63.
• Mukherjee S, Kocher HM, Hutchins RR, Bhattacharya S, Abraham AT. Impact of hospital volume on outcomes for pancreaticoduodenectomy: a single UK HPB centre experience. Eur J Surg Oncol 2009;35(7):734-8.
• Partelli S, Beg S, Brown J, Vyas S, Kocher HM. Alteration in emergency theatre prioritisation does not alter outcome for acute appendicitis: comparative cohort study. World J Emerg Surg 2009;4:22.
• Iype S, Mirza TA, Propper DJ, Bhattacharya S, Feakins RM, Kocher HM. Neuroendocrine tumours of the gallbladder: three cases and a review of the literature. Postgrad Med J 2009;85(1002):213-8.
• Iqbal N, Lovegrove RE, Tilney HS, Abraham AT, Bhattacharya S, Tekkis PP, Kocher HM. A comparison of pancreaticoduodenectomy with pylorus preserving pancreaticoduodenectomy: A meta-analysis of 2822 patients. Eur J Surg Oncol 2009;35(1):79-86.
• Weeks ME, Hariharan D, Petronijevic L, Kocher HM, Timms JF, Lemoine NR, Crnogorac-Jurcevic T. Analysis of urine proteome in patients with pancreatic ductal adenocarcinoma. Proteomics Clinical Applications 2008;2:1047-57.
• Mohamedali A, Lea NC, Feakins RM, Raj K, Mufti GJ, Kocher HM. AKT1 (E17K) mutation in pancreatic cancer. Technol Cancer Res Treat. 2008;7(5):407-8.
• Mukherjee S, Kocher HM, Hutchins RR, Bhattacharya S, Abraham AT. Palliative Surgical Bypass for Pancreatic and Peri-ampullary Cancers. J Gastrointest Cancer 2008;38(2-4):102-7.
• Hariharan D, Abdouslam S, Kocher HM. The analysis of mortality rates for gall bladder cancers across the world. HPB 2008;10(5)327-31.
• Kocher HM. Chronic pancreatitis. Am Fam Physician 2008;77(5):661-2.
• Iqbal N, Lovegrove RE, Tilney HS, Abraham AT, Bhattacharya S, Tekkis PP, Kocher HM. A comparison of pancreaticoduodenectomy with extended pancreaticoduodenectomy: A meta-analysis of 1909 patients. Eur J Surg Oncol 2008;34(11)1237-45.
• Hariharan D, Abdouslam S, Kocher HM. Analysis of mortality rates for pancreatic cancers across the world. HPB 2008;10(1):58-62.
• Al-Ghnaniem, Camprodon RA, Kocher HM, Portmann B, Al-Nawab M, Shaikh H, Sohail M, Patel AG. Strategy to reduce the risk of positive resection margin at pancreatico-duodenectomy. ANZJ Surg 2008;78(4):237-9.
• Gourgiotis S, Kocher HM, Solaini L, Yarollahi A, Tsiambas E, Salemis NS. Gallbladder cancer. Am J Surg 2008;196(2):252-64.
• Mai-Phan TA, Patel B, Walsh M, Abraham AT, Kocher HM. Emergency room surgical workload in an inner city UK teaching hospital. World J Emerg Surg 2008;3:19.
• Kocher HM. Chronic Pancreatitis. BMJ Clin Evid 2007;8:417-31.
• O'Sullivan A, Kocher HM. Pancreatic cancer. BMJ Clin Evid 2007;11:409-36.
• Kocher HM, Lea NC, Raj K, Mears L, Mufti GJ. JAK V617F missense mutation is absent in pancreatic cancer. Gut 2007;56(8):1174-5.
• Germanos S, Gourgiotis S, Kocher HM. Clinical update: early surgery for acute cholecystitis. Lancet 2007;369:1774-6.
• Kocher HM, Sohail M, Benjamin IS, Patel AG. Technical limitations of lymph node mapping in pancreatic cancer. Eur J Surg Oncol 2007;33(7):887-91.
• Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H, Crnogorac-Jurcevic T, Lemoine NR. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta(4) integrin and the PI3k pathway. Oncogene 2007;26:2082-94.
• Kocher HM, Warwick J, Al-Ghnaniem R, Patel A . Surgical dexterity after a 'night out on the town'. ANZ J Surg 2006;76:110-2.
• Kocher HM, Senkus R, Moorhead J, Al-Nawab M, Patel AG, Benjamin IS, Hendry BM. Expression of Ras GTPase isoforms in normal and diseased pancreas. Pancreatology 2005;5:205-14.
• Kocher HM, Tekkis PP, Gopal P, Patel AG, Cottam S, Benjamin IS. Risk-adjustment in hepatobiliary pancreatic surgery. World J Gastroenterol 2005;11:2450-5.
• Kocher HM, Senkus R, Al-Nawab M, Hendry BM. Subcellular distribution of Ras GTPase isoforms in normal human kidney. Nephrol Dial Transplant 2005;20:886-91.
• Loong TP, Kocher HM. Clinical presentation and operative repair of hernia of Morgagni. Postgrad Med J 2005;81:41-4.
• Tekkis PP, Prytherch DR, Kocher HM, Senapati A, Poloniecki JD, StamatakisJD, Windsor AC. Development of a dedicated risk-adjustment scoring system for colorectal surgery (colorectal POSSUM). Br J Surg 2004;91:1174-82.
• Kocher HM, Moorhead J, Sharpe CC, Dockrell ME, Al-Nawab M, Hendry BM. Expression of Ras GTPases in normal kidney and in glomerulonephritis. Nephrol Dial Transplant 2003;18:2284-92.
• Clarke HC, Kocher HM, Khwaja A, Kloog Y, Cook HT, Hendry BM, Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. J Am Soc Nephrol 2003;14:848-54.
• Kocher HM, Tekkis PP. Surgical treatment of esophageal cancer. N Engl J Med. 2003;348:1177-9 (letter).
• Tekkis PP, Kessaris N, Kocher HM, Poloniecki JD, Lyttle J, Windsor AC. Evaluation of POSSUM and P-POSSUM scoring systems in patients undergoing colorectal surgery. Br J Surg 2003;90:340-5.
• Al-Ghnaniem R, Kocher HM, Patel AG. Prediction of inflammation of the appendix at open and laparoscopic appendicectomy: findings and consequences. Eur J Surg 2002;168:4-7.
• Kocher HM, Steward M, Leather AJ, Cullen PT. Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure. Br J Surg 2002;89: 413-7.

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