HomeContact: cancer-pa@qmul.ac.uk
Professional interests
Professor Lemoine is the Director of both the Institute of Cancer and the Cancer Clinical Academic Unit at Barts Hospital, having joined Barts and The London in April 2004. He also leads the Centre for Molecular Oncology & Imaging, where the research of four groups focuses on the molecular pathology of solid malignancies, cancer genomics and bioinformatics, cell survival signalling, and molecular therapeutics including viral gene therapy approaches.
The Centre for Molecular Oncology & Imaging aims to exploit the technologies of functional genomics to develop novel approaches for diagnosis, classification and treatment of human cancers. Advances in knowledge resulting from the sequencing of the human genome and the advent of high-throughput technologies now facilitate simultaneous analysis of the activity of many genes in cells and tissues, and the challenge is to translate such molecular profiles into clinical benefit for patients.
Within the Centre, Professor Lemoine, together with senior investigator Dr Tatjana Crnogorac-Jurcevic, directs the Molecular Pathology research group, located in a state of the art laboratory complex. This offers major new opportunities for molecular analysis of cancer in patients and populations, with access to a wide range of primary cancer samples both from established tissue banks and directly from patients in prospective clinical trials. Current studies use array CGH and high-density SNP analysis for genomic interrogation, as well as oligo microarrays to follow patterns of gene expression. Working closely with the Cancer Bioinformatics Group led by Dr Claude Chelala, this programme is developing new approaches to address questions related to tumour classification and response to therapy in pancreatic and other gastrointestinal malignancies.
Professor Lemoine directs the Gene Therapy research group with senior investigators Professor Iain McNeish, Dr Gunnel Hallden and Dr Yaohe Wang. Their major interests are in oncolytic virotherapy, particularly using selectively replicating adenoviruses and vaccinia viruses, and in defining the cell survival signalling circuits that determine the sensitivity of cancer cells to this approach. The role of the immune system in modulating viral replication and tumour cell destruction is the focus of a major new programme.
Research Teams:
| Molecular Pathology Team | |
| Dr Tatjana Crnogorac-Jurcevic | Senior Lecturer |
| Dr Claude Chelala | Lecturer in Cancer Bioinformatics |
| Mr Vipul Bhakta | Research Assistant |
| Dr Mohammed Ikram | Research Assistant |
| Mr Keyur Trevedi | Research Assistant |
| Post vacant | Bioinformatician |
| Gene Therapy Team | |
| Professor Iain McNeish | Professor of Gynaecological Oncology |
| Dr Gunnel Hallden | Senior Lecturer |
| Dr Yaohe Wang | Senior Lecturer |
| Dr Rathi Gangeswaran | Research Associate |
| Dr Chiat Cheong | Postdoctoral Research Fellow |
| Dr Daniel Oberg | Postdoctoral Research Fellow |
| Dr Guozhong Jiang | Postdoctoral Research Fellow |
Dr Chikkanna Gowda Puttaswamaiah |
Postdoctoral Research Fellow |
Dr Crispin Hiley |
Clinical Research Fellow |
Dr Han Hsi Wong |
Clinical Research Fellow |
| Ms Virginie Adam | PhD Student |
| Ms Katrina Sweeney | Technician |
Funding:
Cancer Research UK Programme Grant (£7.2 million) 2005-2010: Molecular pathology and gene therapy for cancer (C355/A475; C355/A6252; C355/A6253) and Cell survival signalling (C355/A6254)
Cancer Research UK Clinical Centre Core Grant C355/A4975 (£5.9 million) 2004-2009
Cancer Research UK Development Grant (£160K) 2006-2007: Targeting bcl-2 with Gene-ICE constructs (C355/A6254)
Charitable Foundation of Barts & The London (£640K) 2005-2010: Flavell Programme for Prostate Cancer Gene Therapy
Cancer Research UK Centre Equipment Grants (£286K) 2006
Cancer Research UK Graduate Studentship Grant (£100K) 2005-2008: Oncolytic biotherapy for prostate cancer
EU Framework 6 Integrated Project (€640K) 2006-2009: Novel molecular diagnostic tools for the prevention and diagnosis of pancreatic cancer (total value €8.5 million)
Digestive Cancer Campaign Programme Grant (£500K) 2004-2009: Development of novel therapies & biomarkers for pancreatic cancer
Cancer Research UK Competitive Staff Pool Grant (£150K) 2004-2007: The role of S100P in pancreatic tumorigenesis
Key publications in:
All publications from 2001 onwards
