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2010 to date
Hiley C, Yuan M, Lemoine NR, Wang YH. Lister strain vaccinia virus, a potential therapeutic vector targeting hypoxic tumours. Gene Ther 2010:in press. doi: 10.1038/gt.2009.132
2009
Öberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR, Halldén G. Improved potency and selectivity of an oncolytic E1ACR2- and E1B19K-deleted adenoviral mutant (AdΔΔ) in prostate and pancreatic cancers. Clin Cancer Res 2009;16:541-53.
Pardo OE, Latigo J, Jeffery RE, Nye E, Poulsom R, Spencer-Dene B, Lemoine NR, Stamp GW, Aboagye EO, Seckl MJ. The Fibroblast Growth Factor Receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo. Cancer Res 2009;69:8645-51.
Peerlinck I, Merron A, Baril P, Conchon S, Martin-Duque P, Hindorf C, Burnet J, Quintanilla M, Hingorani M, Iggo R, Lemoine NR, Harrington K, Vassaux G. Targeted radionuclide therapy using a Wnt-targeted replicating adenovirus encoding the Na/I symporter. Clin Cancer Res 2009;5(21):6595-601.
Tysome JR, Wang S, Cao F, Yu J, Wang P, Deng L, Li X, Gao D, Alusi G, Fodor I, Francis J, Zhang Y, Dong Z, Lemoine NR, Wang Y. Lister vaccine strain vaccinia virus expressing endostatin-angiostatin fusion gene for therapy of pancreatic cancer. Gene Ther 2009;16(10):1223-33.
Wang Y, Gangeswaran R, Zhao X, Tysome J, Wang P, Bhakta V, Chikkanna Gowda P, Jiang G, Gao D, Cao F, Francis J, Yu J, Liu K, Yang H, Zhang Y, Zang W, Dong Z, Lemoine NR. CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells. J Clin Invest 2009;119:1604-15.
Chelala C, Lemoine NR, Hahn S, Crnogorac-Jurcevic T. A web-based platform for mining pancreatic expression datasets. Pancreatology 2009;9:340-3.
Leitner S, Sweeney K, Öberg D, Miranda E, Lemoine NR, Halldén G. Oncolytic adenoviral mutants with E1B19K-gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumour efficacy in vivo. Clin Cancer Res 2009;15:1730-40.
Chelala C, Khan A, Lemoine NR. SNPnexus: A web database for functional SNPnexus: A web database for functional annotation of newly discovered and public domain Single Nucleotide Polymorphisms. Bioinformatics 2009;25:655-61.
Marinov M, Ziogas A, Pardo OE, Tan LT, Lane HA, Lemoine NR, Zangemeister-Wittke U, Seckl M, Arcaro A. Akt/mTOR pathway activation and Bcl-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001 (Everolimus). Clin Cancer Res 2009;15:1277-87.
Antonello D, Gobbo S, Corbo V, Sipos B, Lemoine NR, Scarpa A. Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma. Pancreatology 2009;9(1-2):25-33.
Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR. Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology 2009;9(1-2):13-24.
2008
Peerlinck I, Amini-Nik S, Phillips RK, Iggo R, Lemoine NR, Tejpar S, Vassaux G. Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors. Clin Cancer Res 2008;14:6187-92.
Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, Harada T, Gangeswaran R, Manson-Bishop C, Smith P, Ali-Danovi S, Pardo O, Crook T, Mein CR, Lemoine NR, Jones JL, Basu S. Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death & Differentiation 2008;15(11):1752-9.
Weeks ME, Hariharan D, Petronijevic L, Radon TP, Whiteman HJ, Kocher HM, Timms JF, Lemoine NR, Crnogorac-Jurcevic T. Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma. PROTEOMICS - Clinical Applications 2008;2:1047-57.
Lemoine NR. The Clinician Scientist: A rare breed under threat in a hostile environment. Disease Models & Mechanisms 2008;1:12-4.
Danovi SA, Wong HH, Lemoine NR. Targeted therapies for pancreatic cancer. British Medical Bul 2008;87(1):97-130.
Wong HH, Lemoine NR. Biological approaches to therapy of pancreatic cancer. Pancreatology 2008;8(4-5):431-61.
Equihua CM, Martin-Duque P, de la Vieja A, Quintanilla M, Burnet J, Vassaux G, Lemoine NR. Targeting sodium/iodide symporter gene expression for oestrogen-regulated imaging and therapy in breast cancer. Cancer Gene Therapy 2008;15: 465-73.
Cheong C, Hill R, Wang Y, Meng JH, Kirn DH, Lemoine NR, Hallden G. E1A-expressing adenoviral E3 mutants act synergistically with chemotherapeutics in immunocompetent tumor models. Cancer Gene Therapy 2008;15:40-50.
Baird SK, Aerts JL, Eddaoudi A, Lockley M, Lemoine NR, McNeish IA. Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer. Oncogene 2008;27:3081-90.
2007
Aiuti A, Bachoud-Lévi A-C, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA, Leen AM, Lemoine NR, McNeish IA, Meneguzzi G, Peschanski M, Roncarolo MG, Strayer DS, Tuszynski MH, Waxman DJ, Wilson JM. Progress and prospects: gene therapy clinical trials (part 2). Gene Therapy 2007;14:1555-63.
Chelala C, Hahn S, White H, Barry S, Harihan D, Radon T, Lemoine NR, Crnogorac-Jurcevic T. Pancreatic Expression Database: a generic model for the organisation, integration and presentation of complex data for cancer research. BMC Genomics 2007;8: 439.
Harada T, Chelala C, Bhakta V, Chaplin T, Caulee K, Baril P, Young BD, Lemoine NR. Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene 2007;27;1951-60.
Whiteman HJ, Weeks ME, Dowen SE, Barry S, Timms JF, Lemoine NR, Crnogorac- Jurcevic T. The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D. Cancer Res 2007;67:8633-42.
Mahon PC, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, Lemoine NR. S100A4 contributes to the suppression of BNIP3 expression, chemoresistance and inhibition of apoptosis in pancreatic cancer. Cancer Res 2007;67:6786-95.
Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D. Cytotoxic action of phorbol esters on human pancreatic cancer cells. Int J Cancer 2007;121:1445-54.
Sheikh AA, Vimalachandran D, Thompson CC, Jenkins RE, Nedjadi T, Shekouh A, Campbell F, Dodson A, Prime W, Crnogorac-Jurcevic T, Lemoine NR, Costello E. The expression of S100A8 in pancreatic cancer-associated monocytes is associated with the Smad4 status of pancreatic cancer cells. Proteomics 2007;7:1929-40.
Pandha H, Rigg A, John J, Lemoine N. Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines. Clin Exp Immunol 2007;148:127-35.
Lopes RB, Gangeswaran R, McNeish IA, Wang Y, Lemoine NR. Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy. Int J Cancer 2007;120:2344-52.
Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H, Crnogorac-Jurcevic T, Lemoine NR. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta(4) integrin and the PI3k pathway. Oncogene 2007;26:2082-94.
Harada T, Baril P, Gangeswaran R, Kelly G, Chelala C, Bhakta V, Caulee K, Mahon PC, Lemoine NR. Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation. Br J Cancer 2007;96:373-82.
Thompson CC, Ashcroft FJ, Patel S, Saraga G, Vimalachandran D, Prime W, Campbell F, Dodson A, Jenkins RE, Lemoine NR, Crnogorac-Jurcevic T, Yin HL, Costello E. Pancreatic cancer cells overexpress Gelsolin family capping proteins which contribute to their cell motility. Gut 2007;6:95-106.
Neesse A, Gangeswaran R, Luettges J, Feakins R, Weeks ME, Lemoine NR, Crnogorac-Jurcevic T. Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. Oncogene 2007;26:1533-45.
Leyton J, Lockley M, Aerts J, Baird SK, Aboagye E,Lemoine NR, McNeish IA. Quantifying the activity of adenoviral E1A CR2 deletion mutants using Renilla luciferase bioluminescence and 3’-Deoxy-3’-[18F] Fluorothymidine PET imaging. Cancer Research 2006;66:9178-85.
Chernajovsky Y, Layward L, Lemoine N. Fighting cancer with oncolytic viruses. BMJ 2006;332:170-2.
Capurso G, Lattimore S, Crnogorac-Jurcevic T, Panzuto F, Milione M, Bhakta V, Campanini N, Swift SM, Bordi C, Delle Fave G, Lemoine NR. Gene expression profiles of progressive pancreatic endocrine tumours and their liver metastases reveal potential novel markers and therapeutic targets. Endocrine-Related Cancer 2006;13:541-58.
Martin-Duque P, Quintanilla M, McNeish I, Lopes R, Romero D, Lemoine NR, Vassaux G. Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo. Int J Mol Med 2006;17:841-7.
Khan SA, Taylor-Robinson SD, Carmichael PL, Habib N, Lemoine NR, Thomas HC. Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma. Int J Oncol 2006;28:1269-77.
Bhattacharyya M, Lemoine NR. Gene therapy developments for pancreatic cancer. Best Pract Res Clin Gastroenterol 2006;20:285-98.
Vassaux G, Nitcheu J, Jezzard S, Lemoine NR. Bacterial gene therapy strategies. J Pathol 2006;208:290-8.
Lockley M, Fernandez M, Wang Y, Li NF, Conroy SE, Lemoine NR, McNeish IA. Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring and intraperitoneal delivery in icodextrin. Cancer Research 2006;66: 989-998.
2005
Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W, Campbell F, Brentnall TA, Costello E, Neoptolemos JP, Lemoine NR. Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology 2005;129:1454-63 .
Smith PG, Fernandez M, Oakley F, Mann DA, Lemoine NR, Whitehouse A. Herpesvirus saimiri-based vector biodistribution using non-invasive optical imaging. Gene Therapy 2005;12:1465-1476.
Liu TC, Wang YH, Hallden G, Brooks G, Francis J, Lemoine NR, Kirn DH. Functional interactions of anti-apoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus. Gene Therapy 2005;12:1333-46.
Lopes R, Castro I, Pontes P, Candeias J, Lemoine NR, Sambade C. Expression profile of survivin in acute leukaemias: the importance of differential splicing. Leukemia 2005;19:1284-6.
Vimalachandran D, Watson R, Thompson C, Greenhalf W, Yan L, Prime W, Campbell F, Dobson A, Crnogorac-Jurcevic T, Lemoine NR, Neoptolemos JP, Costello E. High nuclear S100A6 (calcyclin) is significantly associated with poor survival in pancreatic cancer patients. Cancer Research 2005;65:3218-25.
Akada M, Crnogorac-Jurcevic T, Lattimore S, Mahon CP, Sunamura M, Matsuno S, Lemoine NR. Intrinsic chemoresistance to Gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. Clin Cancer Research 2005;11:3094-101.
Wang YH, Xue SA, Halldén G, Francis J, Yuan M, Griffin BE, Lemoine NR. VAI-deleted adenovirus, a potential oncolytic agent targeting human Epstein-Barr virus (EBV)-associated tumours. Cancer Research 2005;65:1523-31.
Wang YH, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine NR, Kirn D, Hallden G. A novel assay to assess primary human cancer infectibility by replication-selective oncolytic viruses. Clin Cancer Research 2005;11:351360.
Buluwela L, Pike J, Mazhar D, Kamalati T, Hart S, Al-Jehani R, Yahaya H, Patel N, Heathcote D, Schwickerath O, Phoenix F, Hill R, Aboagye E, Shousha S, Waxman J, Coombes RC, Lemoine NR, Zelent A, Ali S. Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-a and the transcriptional repressor PLZF. Gene Therapy 2005;12:452-60.
Missiaglia E, Donadelli M, Palmieri M, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR. Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway. Oncogene 2005;24:199-211.
Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, Eloranta JJ, Bhakta V, Brentnall T, Lüttges J, Klöppel G, Lemoine NR. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. Am J Pathol 2005;166:81-92.
Stoll V, Calleja V, Vassaux G, Downward J, Lemoine NR. Dominant negative inhibitors of signalling through the phosphoinositol 3-kinase pathway for gene therapy of pancreatic cancer. Gut 2005;54:109-16.
McNeish IA, Bell SJ, Lopes R, McKay TR, Fernandez M, Wheatley SP, Lemoine NR. Survivin interacts with Smac/DIABLO and is downregulated, but is dispensable for Smac-mediated apoptosis in ovarian carcinoma cells. Experimental Cell Research 2005;302:69-82.
2004
Pike J, Holmes D, Kamalati T, Tolhurst R, Mazhar D, Fishpool S, Al-Jehani R, Waxman J, Zelent A, Lemoine NR, Ali S, Buluwela L. Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor. Oncogene 2004;23:7561-70.
Savage P, Cowburn P, Clemens D, Hurley T, Laguda B, Martin-Duque P, Vassaux G, Lemoine NR. Suicide gene therapy: conversion of ethanol to acetaldehyde mediated by human beta 2 alcohol dehydrogenase. Cancer Gene Therapy 2004;11:774-81.
Petrovska L, Aspinall RJ, Barber L, Clare S, Simmons CP, Stratford R, Khan SA, Lemoine NR, Frankel G, Holden DW, Dougan G. Salmonella Enterica Serovar Typhimurium interaction with dendritic cells: impact of the sifA gene. Cellular Microbiology 2004;6:1071-84.
Groot-Wassink T, Aboagye EO, Wang YH, Lemoine NR, Keith WN, Vassaux G. Non-invasive imaging of the transcriptional activities of human telomerase promoter fragments in mice. Cancer Research 2004;64:4906-11.
Liu TC, Wang YH, Hallden G, Francis J, Brooks G, Lemoine NR, Kirn DH. Adenovirus E1B-19kD gene deletion enhances oncolytic virus efficacy and in vivo replication-selectivity. Molecular Therapy 2004;9:786-803.
Missiaglia E, Blaveri E, Terris B, Wang Y, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, Lemoine NR. Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. Int J Cancer 2004;112:100-12.
Critchley RJ, Jezzard S, Radford KJ, Goussard S, Lemoine NR, Grillot-Courvalin C, Vassaux G. Potential therapeutic applications of recombinant, invasive E. coli. Gene Therapy 2004;11:1224-33.
Madhusadan S, Bates N, Flanagan E, Gore ME, Barton D, Harper P, Seckl M, Thomas H, Lemoine NR, Charnock M, Habib NA, Lechler R, Pignatelli M, Ganesan TS. A multicentre phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/NEU oncogene. Clinical Cancer Research 2004;10:2986-96.
Kakkar AK, Levine MN, Kadziola Z, Lemoine NR, Low V, Patel HK, Rustin G, Thomas M, Quigley M, Williamson RCN. Low-molecular-weight heparin dalteparin therapy and survival in advanced cancer. J Clin Oncology 2004;22:1944-8.
Groot-Wassink T, Aboagye EO, Wang YH, Lemoine NR, Reader A, Vassaux G. Quantitative imaging of Na/I symporter transgene expression using positron emission tomography in the living animal. Molecular Therapy 2004;9:436-42.
Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR. Role of Bim in the survival pathway induced by Raf in epithelial cells. Oncogene 2004;23:2431-41.
2003
Wang YH, Hallden G, Hill R, Anand A, Liu TC, Francis J, Brooks G, Lemoine NR, Kirn DH. E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models. Nature Biotechnology 2003;21:1328-35.
Shekouh AR, Thompson CC, Prime W, Campbell F, Hamlett J, Herrington CS, Lemoine NR, Crnogorac-Jurcevic T, Buechler MW, Friess H, Neoptolemos JP, Pennington SR, Costello E. Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics 2003;3:1988-2001.
Pardo OE, Lesay A, Arcaro A, Lopes R, Ng BL, Warne PH, McNeish IA, Tetley TD, Lemoine NR, Mehmet H, Seckl MJ, Downward J. FGF-2-mediated translational control of IAP levels blocks release of Smac/DIABLO from mitochondria of small cell lung cancer cells. Mol Cell Biol 2003;23:7600-10.
Hallden G, Hill R, Wang YH, Anand A, Liu TC, Lemoine NR, Francis J, Hawkins L, Kirn DH. Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy. Molecular Therapy 2003;8:412-24.
Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C, Lemoine NR, Hart IR. Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer. Oncogene 2003;22:3742-8.
Radford KJ, Jackson AM, Wang JH, Vassaux G, Lemoine NR. Recombinant E coli delivers antigen and maturation signals efficiently to human dendritic cells: presentation of MART1 to CD8+ T-cells. Int J Cancer 2003;105:81181-9.
McKay T, Bell S, Warnes G, Tenev T, Stoll V, Lemoine NR, McNeish IA. Pro-caspase-3 and Smac/DIABLO expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant negative mutant, survivin T34A; a combination gene therapy strategy. Oncogene 2003;22:3539-47.
McNeish IA, Bell S, McKay T, Tenev T, Stoll V, Lemoine NR. Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a predominantly caspase-9-mediated pathway and enhances sensitivity to cisplatin, paclitaxel and caspase-3. Experimental Cell Research 2003;286:186-98.
2002
Radford KJ, Higgins DE, Cheadle E, Pasquini S, Carta L, Jackson AM, Lemoine NR, Vassaux G. A recombinant E. coli to promote MHC class I-dependent antigen presentation: application to cancer immunotherapy. Gene Therapy 2002;9:1455-63.
Groot-Wassink T, Aboagye EO, Glaser M, Lemoine NR, Vassaux G. Adenovirus biodistribution and non-invasive imaging in vivo by positron emission tomography using the human sodium/iodide symporter as a reporter gene. Human Gene Therapy 2002;13:1723-35.
Crnogorac-Jurcevic T, Efthimiou E, Neilsen T, Loader J, Terris B, Stamp GWH, Keating S, Baron A, Scarpa A, Lemoine NR. Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene 2002;21:4587-94.
Marani M, Tenev T, Hancock D, Downward J, Lemoine NR. Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol Cell Biol 2002;22:3577-89.
Terris B, Blaveri E, Crnogorac-Jurcevic T, Jones M, Missiaglia E, Rusziewski P, Sauvanet A, Lemoine NR. Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas. Am J Pathol 2002;160:1745-54.
Tagawa T, Manvell M, Brown N, Murray K, Perouzel E, Keller M, Harbottle R, Tecle M, Frank Booy F, Fellowes R, Coutelle C, Lemoine NR, Alton EWF, Miller AD. Formulation and efficacy of gene delivery mediated by self-assembly LMD vectors derived from combinations of cationic liposomes, adenovirus core peptide m and plasmid DNA. Gene Therapy 2002;9:564-76.
Savage P, Cowburn P, Clayton A, Man S, Ogg G, Lemoine NR, Epenetos AA, McMichael A. Induction of peptide-specific CTL responses with antibody-targeted HLA class I peptide complexes. Br J Cancer 2002;86:1336-42.
Missiaglia E, Moore PS, Williamson J, Lemoine NR, Scarpa A. Sex chromosome anomalies in pancreatic endocrine tumours. Int J Cancer 2002;98:532-8.
Pasquini S, Peralta S, Missiaglia E, Carta L, Lemoine NR. Prime-boost vaccines encoding an intracellular idiotype/GM-CSF fusion protein induce protective cell-mediated immunity in murine pre-B cell leukemia. Gene Therapy 2002;9:503-10.
Savage P, Cowburn P, Clayton A, Man S, Ogg G, Lemoine NR, McMichael A, Epenetos AA. Antiviral cytotoxic T cells inhibit the growth of cancer cells bearing antibody targeted HLA class I/peptide complexes in SCID mice. Int J Cancer 2002;98:561-6.
Martins LM, Iaccarino I, Tenev T, Gschmeissner S, Totty NF, Lemoine NR, Savopoulos J, Gray CW, Creasy CL, Dingwall C, Downward J. The serine protease Omi/HtrA2 promotes apoptosis by interaction with XIAP through a Reaper motif. J Biol Chem 2002;277:439-44.
2001
Crnogorac-Jurcevic T, Efthimiou E, Capelli P, Blaveri E, Terris B, Baron A, Jones M, Tyson K, Bassi C, Scarpa A, Lemoine NR. Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene 2001;20:7437-46.
Rigg AS, Lemoine NR. Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behaviour of pancreatic cancer and have a significant anti-tumour effect in vivo. Cancer Gene Therapy 2001;8:869-78.
El-Hariry I, Pignatelli M, Lemoine NR. FGF-1 and FGF-2 regulate the expression of E-cadherin and catenins in pancreatic adenocarcinoma. Int J Cancer 2001;94:652-61.
McNeish IA, Tenev T, Bell S, Marani M, Vassaux G, Lemoine NR. Herpes simplex virus thymidine kinase/ganciclovir-induced cell death is enhanced by co-expression of caspase-3 in ovarian cancer cells. Cancer Gene Therapy 2001;8:308-19.
Tenev T, Marani M, McNeish I, Lemoine NR. Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors. Cell Death & Differentiation 2001;8:256-64.
Ghaneh P, Greenhalf W, Humphreys M, Wilson D, Zumstein L, Lemoine NR, Neoptolemos JP. Adenovirus-mediated transfer of p53 and p16INK4A results in pancreatic cancer regression in vitro and in vivo. Gene Therapy 2001;8:199-207.
Sirivatanauksorn V, Sirivatanauksorn Y, Gorman P, Davidson J, Sheer D, Moore P, Scarpa A, Edwards P, Lemoine NR. Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. Int J Cancer 2001;91:350-8.
Review Articles & Editorials:
Wong HH, Lemoine NR, Wang Y. Oncolytic viruses for cancer therapy: overcoming the obstacles. Viruses 2010;in press.
Tysome JR, Lemoine NR, Wang Y. Combining anti-angiogenic therapy and virotherapy: arming oncolytic viruses with anti-angiogenic genes. Curr Opin Mol Ther 11: 664-669.
Wong HH, Lemoine NR. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat Rev Gastroenterol Hepatol 2009;6:412-22.
Antonello D, Gobbo S, Corbo V, Sipos B, Lemoine NR, Scarpa A. Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma. Pancreatology 2009;9:25-33.
Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR. Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology 2009;9:13-24.
Lemoine NR. The Clinician Scientist: A rare breed under threat in a hostile environment. Dis Model Mech 2008;1:12-4.
Danovi SA, Wong HH, Lemoine NR. Targeted therapies for pancreatic cancer. Br Med Bull 2008;87:97-130.
Wong HH, Lemoine NR. Biological approaches to therapy of pancreatic cancer. Pancreatology 2008;8:431-61.
Aiuti A, Bachoud-LŽvi A-C, Blesch A, Brenner MK, Cattaneo F, Chiocca EA, Gao G, High KA, Leen AM, Lemoine NR, McNeish IA, Meneguzzi G, Peschanski M, Roncarolo MG, Strayer DS, Tuszynski MH, Waxman DJ, Wilson JM. Progress and prospects: gene therapy clinical trials. Gene Ther 2007;14:1555-63.
Chernajovsky Y, Layward L, Lemoine NR. Fighting cancer with oncolytic viruses: proceed with caution. British Medical Journal 2006;332:170-2.
Bhattacharyya M, Lemoine NR. Gene therapy developments for pancreatic cancer. Best Pract Res Clin Gastroenterol 2006;20:285-98.
Vassaux G, Nitcheu J, Jezzard S, Lemoine NR. Bacterial gene therapy strategies. J Pathol 2006;208:290-8.
Lemoine NR. Silencing RNA - a novel treatment for pancreatic cancer? Gut 2005;54:1215-6.
Petralia GA, Lemoine NR, Kakkar AK. The impact of antithrombotic therapy in cancer patients. Nature Clinical Practice Oncology 2005;2:356-63.
Lemoine NR. Antithrombotic therapy in cancer. J Clin Oncol 2005;23:2119-20.
Burn J, Lemoine NR, O'Toole L. Assessing cancer risk. Expert Rev Anticancer Ther 2004;4:S13-7.
Lemoine NR, McNeish IA. Gene transfer: Bax to the future for cancer therapy. Gut 2004;53:478-9.
McNeish IA, Bell S, Lemoine NR. Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes. Gene Therapy 2004;11:497-503.
Lemoine NR, Kirby RB. UK cash for gene therapy: Government pledges support. Gene Therapy 2003;10:1405-6.
Groot-Wassink T, Barthel H, Lemoine NR, Vassaux G. Sodium iodide symporter: a new strategy to target cancer? Lancet 2003;3611905-6.
Lemoine NR. Risks and benefits of gene therapy for immunodeficiency: a reality check. Gene Therapy 2002;9:1561-2.
Harrington K, Alvarez-Vallina L, Crittenden M, Gough M, Chong H, Diaz RM, Vassaux G, Lemoine NR, Vile R. Cell carriers for cancer gene therapy: bridging the gap between targeted vectors and systemic delivery? Human Gene Therapy 2002;13:1263-80.
Lemoine NR. The power to deliver: stem cells in gene therapy. Gene Therapy 2002;9:603-5.
Hawkins L, Lemoine NR, Kirn DH. Oncolytic biotherapy: a novel therapeutic platform. Lancet Oncology 2002;3:17-26Efthimiou E, Crnogorac-Jurcevic T, Lemoine NR. Pancreatic cancer genetics. Pancreatology 2001;1:571-5.
Efthimiou E, Crnogorac-Jurcevic T, Brentnall T, Lemoine NR. Inherited predisposition to pancreatic cancer. Gut 2001;48:143-7.