Contact: m.raghavan@qmul.ac.uk

Professional interests

Manoj Raghavan joined the Institute of Cancer in October 2007 funded by a Kay Kendall Intermediate Fellowship. He underwent specialist training in Haematology at University College Hospital, London from 1998 and completed his PhD training at the Institute of Cancer. The research used high-resolution genotyping of acute myeloid leukaemia and identified frequent regions of acquired uniparental disomy (UPD) due to mitotic recombination.
 
His current research continues to analyse genomic changes in the DNA of relapsed AML, using microarray technologies that cover the whole genome and investigates whether their low-level presence at diagnosis can predict who may relapse.

 

Funding:

Kay Kendall Leukaemia Fund Intermediate Fellowship 3 years £363,233

Recent Publications:

• Raghavan M, Smith LL, Lillington DM, Chaplin T, Kakkas I, Molloy G, Chelala C, Cazier JB, Cavenagh JD, Fitzgibbon J, Lister TA, Young BD. Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia. Blood 2008;112(3):814-21.
• Gupta M, Raghavan M, Gale RE, Chelala C, Allen C, Molloy G, Chaplin T, Linch DC, Cazier JB, Young BD. Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia. Genes Chromosomes Cancer 2008;47(9):729-39.
• Fitzgibbon J, Iqbal S, Davies A, O'Shea D, Carlotti E, Chaplin T, Matthews J, Raghavan M, Norton A, Lister TA, Young BD. Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma. Leukemia 2007;21(7):1514-20.
  
• Purdie KJ, Lambert SR, Teh MT, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM, Harwood CA, Proby CM, Young BD. Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer 2007;46(7):661-9.
• Bungaro S, Raghavan M, Dell'Oro MG, Paolucci P, Young BD, Biondi A, Cazzaniga G. Assessment of submicroscopic genetic lesions by single nucleotide polymorphism arrays in a child with acute myeloid leukemia and FLT3-internal tandem duplication. Haematologica 2006;91(7):998-1000.
• Young BD, Debernardi S, Lillington DM, Skoulakis S, Chaplin T, Foot NJ, Raghavan M. A role for mitotic recombination in leukemogenesis. Adv Enzyme Regul 2006;46:90-7.
• Strefford JC, van Delft FW, Robinson HM, Worley H, Yiannikouris O, Selzer R, Richmond T, Hann I, Bellotti T, Raghavan M, Young BD, Saha V, Harrison CJ. Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Proc Natl Acad Sci U S A. 2006;103(21):8167-72.
• Raghavan M, Lillington DM, Skoulakis S, Debernardi S, Chaplin T, Foot NJ, Lister TA, Young BD. Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias. Cancer Res 2005;65(2):375-8.
• Fitzgibbon J, Smith LL, Raghavan M, Smith ML, Debernardi S, Skoulakis S, Lillington D, Lister TA, Young BD. Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias. Cancer Res 2005;65(20):9152-4.
• Lu YJ, Yang J, Noel E, Skoulakis S, Chaplin T, Raghavan M, Purkis T, McIntyre A, Kudahetti SC, Naase M, Berney D, Shipley J, Oliver RT, Young BD. Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development. Cancer Res 2005;65(20):9137-41.
• Teh MT, Blaydon D, Chaplin T, Foot NJ, Skoulakis S, Raghavan M, Harwood CA, Proby CM, Philpott MP, Young BD, Kelsell DP. Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event. Cancer Res 2005;65(19):8597-603.

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